Clinical trial suggests an anti-inflammatory drug could relieve difficult-to-treat depression

The Limitations of the Monoamine Hypothesis For decades, the pharmacological treatment of major depressive disorder (MDD) has been dominated by the monoamine hypothesis. This theory posits that depression is primarily…

Ancient Chinese Exercise Practice Demonstrates Significant Blood Pressure Reduction, Rivals Brisk Walking in Clinical Trial

An ancient Chinese exercise practice that combines slow movements, controlled breathing, and meditation may help lower blood pressure as effectively as brisk walking, according to a large randomized clinical trial…

The Promise and Peril of Anti-Amyloid Drugs for Alzheimer’s Disease: A Landmark Review Casts Doubt on Clinical Efficacy and Highlights Safety Concerns

A comprehensive and influential Cochrane review has delivered a significant blow to the long-held therapeutic strategy targeting amyloid beta proteins in the brain for Alzheimer’s disease, concluding that these drugs…

Weight-loss drug semaglutide reduces heavy alcohol drinking in new clinical trial

A landmark clinical trial has demonstrated that semaglutide, the active pharmaceutical ingredient in widely used weight-loss and diabetes medications such as Wegovy and Ozempic, may offer a significant new therapeutic…

A Randomized Clinical Trial of Repeated Doses of Psilocybin for the Treatment of Obsessive Compulsive Disorder

A landmark clinical trial published in the Journal of Psychopharmacology has provided new evidence that psilocybin, the primary psychoactive compound found in certain species of fungi, may offer a transformative…

Can Psychopaths Change? New Research Challenges Decades of Clinical Pessimism and Explores More Effective Interventions

While psychopaths represent a mere fraction of the global population—estimated at roughly 1%—their impact on the criminal justice system and public safety is profound and disproportionate. For decades, the prevailing…